| Probiotikas. |
[Jun. 27th, 2024|05:31 pm] |
Kā lai tās, kas šaibās un uz kurām vārās farmakoloģijas nozare (brīvais tirgus ftw), strādā, ja cilvēks apēd tikai mikroorganismus, bet neapēd neko, ko tie nabaga organismi varētu konsumēt. Tās probiotikas, kas ir pārtikā, strādā jau labāk, jo tiek apēsts vismaz nedaudz attiecīgajiem organismiem piemērotās paikas. Attiecīgi pēc antibiotiku lietošanas, lielākajai daļai "labo" mikrobu ir izveikts genocīds, savukārt daļa patogēno izdzīvo, un tad vēl ir tādi multirezistentie, kas 100% izdzīvo. Attiecīgi samest tādā mikrobiomā "labos" mikrobus bez paikas šķiet absolūti bezjēdzīgi, jo "sliktie" parasti ir visnotaļ agresīvi un nez vai ļaus "labajiem" gaidīt labos laikus, kad uzradīsies paika.
Tas, cik svarīgi ir ēst pārtiku, kura satur pēc iespējas daudz un dažādas šķiedrvielas (30 dažādi augi nedēļā), kaut ko fermentētu, kaut ko pa taisno no dārza, šķiet ļoti pašsaprotami, jo nav labāku pro, pre, pos utt biotiku kā tās, kas pārtikā un uz tās. Jo daudzveidīgāka sistēma, jo tā ir stabilāka, tas attiecas arī uz mikrobiomu.
Lūk tā man šodien rādās. |
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| Kāpēc šķiedrvielas ir svarīgi. |
[Jun. 25th, 2024|07:57 pm] |
Introduction: Tryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites implicated in both beneficial and adverse host effects. How gut microbial tryptophan metabolism is directed towards indole, associated with chronic kidney disease, or towards protective indolelactic acid (ILA) and indolepropionic acid (IPA) is unclear.
Methods: Here we used in vitro culturing and animal experiments to assess gut microbial competition for tryptophan and the resulting metabolites in a controlled three-species defined community and in complex undefined human faecal communities.
Results: The generation of specific tryptophan-derived metabolites was not predominantly determined by the abundance of tryptophan-metabolizing bacteria, but rather by substrate-dependent regulation of specific metabolic pathways. Indole-producing Escherichia coli and ILA- and IPA-producing Clostridium sporogenes competed for tryptophan within the three-species community in vitro and in vivo. Importantly, fibre-degrading Bacteroides thetaiotaomicron affected this competition by cross-feeding monosaccharides to E. coli. This inhibited indole production through catabolite repression, thus making more tryptophan available to C. sporogenes, resulting in increased ILA and IPA production. The fibre-dependent reduction in indole was confirmed using human faecal cultures and faecal-microbiota-transplanted gnotobiotic mice.
Conclusion: Our findings explain why consumption of fermentable fibres suppresses indole production but promotes the generation of other tryptophan metabolites associated with health benefits.
https://www.nature.com/articles/s41564-024-01737-3
Triptofāns ir serotonīna prekursors. Šķiedrvielas ir antidepresants. (Tā es tikko izdomāju) |
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[Oct. 3rd, 2023|07:56 pm] |
Interesanti par zarnu mikrofloru
"Our gut microbiome is connected to our brain through chemicals and neurotransmitters, playing a key role in our mental health and overall well-being." |
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