Natūra, 06 December 2023: N¹-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

Random komentātors: Lol hearing frameshifting with ANYTHING to do with DNA is NEVER good.

Here we demonstrate that incorporation of N¹-methylpseudouridine into mRNA results in +1 ribosomal frameshifting in vitro and that cellular immunity in mice and humans to +1 frameshifted products from BNT162b2 vaccine mRNA translation occurs after vaccination.

it is conceivable that other mistranslation events (such as leaky scanning) could also contribute to T cell responses to +1 frameshifted peptide antigens.

These findings are of particular importance to our fundamental understanding of how ribonucleotide modification affects mRNA translation, and for designing and optimizing future mRNA-based therapeutics to avoid mistranslation events that may decrease efficacy or increase toxicity.

#elementāra-klavierspēle #ilgtermiņa-hujilgtermiņa #kas-iepists-tas-iepists #tad-jau-redzēs-papildspēles-rezultātus