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The first mRNA vaccine was developed by Katalin Karikó and Drew Weissman at the University of Pennsylvania in the early 2000s. However, the concept of using mRNA as a vaccine has been around for decades and has been studied by many researchers. The COVID-19 vaccines that have been developed by Moderna and Pfizer-BioNTech are based on this technology and have been shown to be highly effective at preventing infection with the SARS-CoV-2 virus.