"According to Lester Greenspoon, M.D., former associate professor of psychiatry at the Harvard Medical School, the hypothetical lethal dose of marijuana is 40,000 times the psychoactive dose.* The lethal dose of alcohol, a legal drug, is 4 to 10 times the psychoactive dose. The figure for marijuana is hypothetical in that is has only been shown to be true in rats; there are no records of lethal marijuana overdose in humans anywhere."
*"The psychoactive dose for marijuana is about a 1 g joint. That's 40,000 grams of marijuana all within 15 minutes."