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Physiological Action—This agent is a powerful poison to all living protoplasm. It coagulates the blood and destroys the integrity of the corpuscles.

Injected into the veins it causes dyspnea, thrombosis in the vessels and arrest of respiration. Toxic doses produce tremors, muscular contractions, central paralysis, collapse, coma, a violent fall of the temperature and death.

It is a narcotic, and in toxic doses causes nausea, vomiting, faintness, pain in the joints, numbness of the limbs, dryness of the mouth, convulsive movements, a small hard pulse, paralysis of the tongue, a purplish color of the face and hands, twitching of the eyelids and lips, trembling of the limbs, erythematous eruption, suppression of venereal desire, though recovery has followed after very large doses. Clarus administered six grains of solanine, which produced general cephalic distress, with occipital pain, increase of the frequency and loss of the force of the pulse, followed after some hours by sudden vomiting, diarrhea, great weakness, and marked dyspnea.

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