December 2nd, 2006

"Females live longer than males in many mammalian species, including humans. This natural phenomenon can be explained on the basis of the mitochondrial theory of aging. Mitochondria are a major source of free radicals in cells. Mitochondria from female rats generate half the amount of hydrogen peroxide than those of males and have higher levels of mitochondrial reduced glutathione. The latter is due to females behaving as double transgenic in over-expressing antioxidant enzymes. Estrogens bind to the estrogen receptors and subsequently activate the mitogen activated protein (MAP) kinase and nuclear factor kappa B (NFkappaB) signalling pathways, resulting in an upregulation of antioxidant enzymes. Moreover, the 16S rRNA expression, which decreases significantly with aging, is four times higher in mitochondria from females than in those from males of the same chronological age. On the contrary, the oxidative damage of mitochondrial DNA is fourfold higher in males than in females. Ovariectomy abolishes the gender differences between males and females and estrogen replacement rescues the effect of ovariectomy. The challenge for the future is to find molecules that have the beneficial effects of estradiol, but without its feminizing effects. Phytoestrogens or phytoestrogen-related molecules may be good candidates to meet this challenge." Front Biosci. 2007 Jan 1;12:1008-13.
Diemžēl šis gan ir tikai abstrakts, nevis pilns raksts, kkad janvārī būs jāpaskatās PubMed, vai nav par brīvu pieejams pilnais raksts.
Bet nu principā nedaudz cilvēciskākā valodā - jūs, dārgās daiļā dzimuma pārstāves, papildus pienākumam uzņemties smagāko daļu no sugas turpināšanas, mazākai muskuļu un smadzeņu masai un lielākai tauku masai esat no dabas saņēmušas kko varen noderīgu. Jūsu gēnos ir ierakstīts, ka Jūsu ķermenis dzīvo ilgāk, lēnāk sevi sabeidz un dedzīgāk sevi labo. Un nē, mēs, stiprie(vājie?) vīrieši ne jau tikai trakāka dzīvesveida dēļ dzīvojam īsāku mūžu - mums vnk nav jaukā estrogēna tik daudz... Tātad dilemma-dzīvot ilgu mūžu kā parodijai par vīrieti vai dzīvot īso vīrieša mūžu? Bet nē, es taču esmu topošais ķīmiķis, es noteikti atradīšu trešo ceļu :D
Have a nice day, dear charming (and long-living :D) girls! :)

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